The Role of T regulatory Cells (Tregs) in the Development and Prevention of Type 1 Diabetes
نویسندگان
چکیده
In this article, we review the role of T regulatory cells (Tregs) in the development and prevention of type 1 diabetes. We first examine the definition of human Tregs, the generation of Tregs in the thymus and the periphery, their mode of action and their important role in the regulation of the immune response. We then examine the defects in Tregs observed thus far in type 1 diabetes and their role in the development of the disease. Finally, we point to possible clinical applications using Tregs as a therapeutic target for the prevention of type 1 diabetes. The Role of T regulatory Cells (Tregs) in the Development and Prevention of Type 1 Diabetes Stavroula A. Paschou1, Stelios Tigas1, Katerina Naka2, George K. Papadopoulos3* and Agathocles Tsatsoulis1* 1Department of Endocrinology, University of Ioannina, GR45110 Ioannina, Greece 2Department of Cardiology, University of Ioannina, GR45110 Ioannina, Greece 3Laboratory of Biochemistry and Biophysics, Faculty of Agricultural Technology, Epirus Institute of Technology, GR47100 Arta, Greece
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